Gastric granular cell tumor masquerading as gastrointestinal stromal tumor: a rare concept
Gastroenterology and Hepatology from Bed to Bench,
Vol. 18 No. 3 (2025),
26 August 2025
https://doi.org/10.22037/ghfbb.v18i3.3180
Abstract
Granular cell tumor (GCT) is a rare, usually benign neoplasm of Schwann cell origin, infrequently seen in the gastrointestinal tract, especially the stomach. We report an atypical gastric GCT in a 42-year-old female presenting with dysphagia and weight loss, initially suspected to be a gastrointestinal stromal tumor (GIST). Endoscopic and radiological evaluations revealed a submucosal lesion at the gastric cardia. Surgical resection and histopathology confirmed atypical GCT, characterized by PAS-positive granular cytoplasm and immunopositivity for S100, NSE, and CD68. Differentiation from GIST is crucial due to differing management.
- Gastrointestinal stromal tumors
- Tumor and Polyp.
- immunohistochemistry
- Gastric polyps
How to Cite
References
Patti R, Almasio PL, Di Vita G. Granular cell tumor of stomach: a case report and review of literature. World J Gastroenterol 2006;12:3442-3445.
Ramai D, Lai J, Changela K, Anand S. Colonic granular cell tumor: an endoscopic and histopathologic review with case illustration. Cureus 2018;10:e2015.
An S, Jang J, Min K, Kim MS, Park H, Park YS, et al. Granular cell tumor of the gastrointestinal tract: histologic and immunohistochemical analysis of 98 cases. Hum Pathol 2015;46:813-819.
Ofori E, Ramai D, Lui YX, Reddy M. Esophageal granular cell tumor: a case and review of the literature. Gastroenterology Res 2017;10:372-375.
Krishnan A, Ramakrishnan R, Menon M. Endoscopic removal of granular cell tumors of stomach: case report and review of literature. Gastroenterology Res 2013;6:240-243.
Fanburg-Smith JC, Meis-Kindblom JM, Fante R, Kindblom LG. Malignant granular cell tumor of soft tissue: diagnostic criteria and clinic pathologic correlation Am J Surg Pathol 1998;22:779-794.
Kawai M, Goda N, Nikaido M, Fukuda A. A case of gastric granular cell tumor. JGH Open 2021;5:966-967.
Li H, Zhang M, Zheng Y, Zhang H. Gastric granular cell tumor: a case report and literature review. Oncol Lett 2024;28:403.
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