Background: To quantitatively examine the association between the negative outcome of infertility treatment and psychological disorders in infertile women and to determine any difference in their post-treatment mental health compared to those who had a successful cycle.

Materials and Methods: This study included sixty-one infertile women who underwent infertility treatment between December 2022 and July 2023. Their mental health status was assessed with three self-reported measurement tools before the treatment and again after identifying the pregnancy test result.

Results: Women who had a positive test result were recruited into the successful group (n=13), and those with a negative test were included in the unsuccessful group (n=48). Women who had an unsuccessful treatment showed a significant increase in their levels of depression, anxiety, stress, hopelessness, and grief (P-value < 0.001). In comparison between women with successful and unsuccessful treatment, infertile women in the unsuccessful group showed higher levels of depression, anxiety, stress, hopelessness, and grief after the treatment (P-value <0.001).

Conclusion: An unsuccessful treatment may potentially increase infertile women's psychological disorders. This suggests that addressing the psychological aspect alongside infertility treatments for infertile women may help achieve a comprehensive treatment approach.

Hypohidrotic ectodermal dysplasia (HED) is a rare genetic disorder that affects multiple body systems and is characterized by a triad of symptoms that impact hair, teeth, and sweat glands. Diagnosis of HED is primarily based on physical features and is confirmed through genetic testing. Currently, the available treatment options for HED are limited to general medical interventions such as the use of skincare products and prosthetic dental treatment. We present a patient with HED who exhibited typical symptoms in the face and oral cavity. The patient was treated with a topical combination therapy for severe dyskeratosis. The purpose of this report is to increase awareness of HED within the dermatology community and provide information on its diagnosis and management also early diagnosis can enable prompt intervention, relevant therapy and support.