Effects of 2-Alkylamino-Substituted Dihydropyridines on Rabbit Jejunum Effect of substituted dihydropyridines on jejunum
Iranian Journal of Pharmaceutical Sciences,
Vol. 1 No. 1 (2005),
15 Dey 2005
,
Page 27-31
https://doi.org/10.22037/ijps.v1.39438
Abstract
In order to investigate the effects of dimethylamino substituent at postion 2 of the dihydropyridine nucleus on its activity, dialkyl 1,4-dihydro-2-[2-dimethylamino)
ethyl]-6-methyl-4-(1-benzyl-2-alkylthio-5-imidazolyl)-3,5-pyrdinedicarboxylates (6a-f) were synthesized. The synthesis was started from dialkyl 1,4-dihydro-2,6-dimethyl-4-(1-benzyl-2-alkylthio-5-imidazolyl)-3,5-pyridinedicarboxylates (5a-f) which their synthesis and effects as calcium channel antagonist on guinea-pig ileum has been reported previously. Rabbit jejunum was used to determine the relaxant or antagonistic activity of the synthesized compounds.
Some of the compounds (6c-e) inhibited the spontaneous contractile activity of jejunum, dose-dependently and completely, while high-K+ contracted tissues were
relaxed partially.
- 2-Dimethylamino-substituted dihydropyridines
- Rabbit jejunum
- Calcium channel
How to Cite
References
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