Synthesis of pH Sensitive Hydrogels Based on Poly Vinyl Alcoholand Poly Acrylic Acid Synthesis of pH sensitive hydrogels5
Iranian Journal of Pharmaceutical Sciences,
Vol. 4 No. 4 (2008),
1 Mehr 2008
,
Page 275-280
https://doi.org/10.22037/ijps.v4.41057
Abstract
In this research, hydrogels based on poly vinyl alcohol and poly acrylic acid blend were prepared which were cross-linked by applied thermal conditions. Afterward,effects of time and heating on water uptake were investigated. The highest wateruptake value exhibited by the sample that was heated for 20 min. at 110 ºC was about 2129% after 4 days at equilibrium state. Hydrogels exhibited pH-sensitive behaviors in a way that decreasing pH values down to 4.8 did not have any effect on the hydrogels size, whereas with increasing pH upto 8, the hydrogels were expanded.These synthetic hydrogels were evaluated as a controlled drug delivery systems and theophylline released concentration was measured by UV-spectrophotometeric method at different pH values.In vitrobiocompatibility experiments were undertaken using L-929 mouse fibroblast cell lines where the results showed appropriate cellattachment and cell spreading with spindle like morphologies.
Keywords:
- Biocompatibility
- Controlled drug release system
- pH-Sensitive hydrogels
- Poly acrylic acid
- Poly vinyl alcohol
How to Cite
Zahra Fahimi, Maryam Parviz, Fariba Orang, & Shahin Bonakdar. (2008). Synthesis of pH Sensitive Hydrogels Based on Poly Vinyl Alcoholand Poly Acrylic Acid: Synthesis of pH sensitive hydrogels5. Iranian Journal of Pharmaceutical Sciences, 4(4), 275–280. https://doi.org/10.22037/ijps.v4.41057
References
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[25]Lehoussel J, Watteis D, Marechal E. Preparation de membranes echangeuses de cations par photogreffage d'ethers allyliques du poly (alcool vinylique). Etude de certaines de leurs proprietes-II: Photogreffage des poly (alcools vinyliques)allyles.Eur Polym J1979; 15: 915-8.
[26]Shin HS, Kim SY, Lee YM, Lee KH, Kim SJ,Rogers C. Permeation of solutes through interpen-etrating polymer network hydrogels composed of poly(vinyl alcohol) and poly(acrylic acid). J Appl Polym Sci1998; 69: 479-86.
[27]Byun J, Lee YM, Cho C. Swelling of thermosen-sitive interpenetrating polymer networks composed of poly(viny1 alcohol) and poly(acry1icacid). J Appl Polym Sci1996; 61:697-702.
[28]Shin HS, Kim SY, LeeYM. Indomethacin releasebehaviors from pH and thermoresponsive poly(vinyl alcohol) and poly(acrylic acid) IPN hydrogels for site-specific drug delivery. J Appl Polym Sci1997; 65: 685-93.[29]Metayer M, Chamekh OM. Semi-interpenetrating networks (sIPN). Preparation of ion-exchange membranes, using a gaseous crosslinking reagent.React Funct Polymorph1996; 33: 311.
[30]Marra SP, Ramesh KT, Douglas AS. Mechanical characterization of active poly(vinyl alcohol)-poly(acrylic acid) gel.Mater Sci Eng2001; 14:25-34.
[31]Fei J, Zhang Z, Zhong L, Gu L. PVA/PAA thermo-induced hydrogel fiber: Preparation and pH-sensitive behavior in electrolyte solution.J Appl Polym Sci2002; 85: 2423-30.
[2]Osada Y, Gong J. Stimuli-responsive polymer gels and their application to chemomechanical systems. Prog Polym Sci 1993; 18: 187-226.
[3]Tatara Y. Mechanochemical actuators. Adv Robotics1987; 2: 69-85.
[4]Kuckling D, Richter A, Arndt K F. Temperature and pH dependent swelling behavior of poly (N-isopropyl-acrylamide)-copolymer hydrogels and their use in flow control. Macromol Mater Eng2003; 288: 144-51.[5]Gulch R W, Weible A, Wallmersperger T. Char-acterization of electroactive behavior and of progress in developments and applications ofionic polymer gels. In: Bar-Cohen Y, (editor).Proceedings of the SPIE on smart structures and materials: Electroactive polymer actuators and devices. San Diego, 2002; 4695: 367-77.
[6]Richter A, Kuckling D, Arndt KF, Gehring T,Howitz S. Electronically controllable microvalves based on smart hydrogels: Magnitudes and potential applications. J Microelectromechani-cal2003; 12: 5: 748-53.[7]Arndt KF, Richter A, Ludwig S, Zimmermann J,Kressler J, Kuckling D, Adler HJ. Poly(vinyl alcohol)/poly(acrylic acid) hydrogels: FT-IR spectroscopic characterization of crosslinking reactionand work at transition point. Acta Polym 1999; 50: 383-90.
[8]Beebe DJ, Moore JS, Bauer JM, Yu Q, Liu RH,Devadoss C, Jo BH. Functional hydrogel structures for autonomous flow control inside microfluidic channels. Nature2000; 404: 588-90.
[9]Bashir R, Hilt JZ, Elibol O, Gupta A, Peppas NA. Micromechanical cantilever as an ultrasensitive pH microsensor. Appl Phys Lett 2002; 81: 3091-3.
[10]Guenther M, Suchaneck G, Sorber J, Gerlach G,Arndt KF, Richter A. pH sensors based on polymeric hydrogels. Fine Mech Opt(Olomouc)2003; 48: 320-2.
[11]Marshall AJ, Blyth J, Davidson CAB, Lowe CR.pH sensitive holographic sensors. Anal Chem 2003; 75: 4423-31.
[12]Richter A, Bund A, Keller M, Arndt KF. Charac-terization of a microgravimetric sensor based on pH sensitive hydrogels. Sensor Actuator B2004;99: 579-85.
[13]Gerlach G, Guenther M, Suchaneck G, Sorber J,Arndt KF, Richter A. Application of sensitive hydrogels in chemical and pH sensors. Macromol Symp2004; 210: 403-10.
[14]Arndt KF, Kuckling D, Richter A. Application of sensitive hydrogels in flow control. Polym Adv Technol2000; 11: 496-505.
[15]Arndt KF, Schmidt T, Menge H. Poly (vinyl methyl ether) hydrogel formed by high energy irradiation. Macromol Symp2001; 164: 313-22.
[16]Liu X, Zhang X, Cong J, Xu J, Chen K.Demonstration of etched cladding fiber Bragg-grating-based sensors with hydrogel coating.Sensor Actuator B 2003; 96: 468-72.
[17]Kurauchi T, Shiga T, Hirose Y, Okada A.Deformation behaviors of polymer gels. In:DeRossi D, Kajiwara K, Osada Y, Yamuchi A,(editors). Polymer gels. New York: Plenum Press,1991; pp. 237-46.
[18]Bar-Cohen Y, Leary S, Shahinpoor M, Harrison JO, Smith J. Flexible low-mass devices and mechanisms actuated by electroactive polymers.Proc SPIE 1999; 3669: 51-6.
[19]Okano T, Yoshida R, Sakai K, Sakurai Y. Thermo-responsive polymeric hydrogels and their applications to pulsatile drug release. In: DeRossiD, Kajiwara K, Osada Y, Yamuchi A, (editors).Polymer gels. New York: Plenum Press, 1999;pp.299-308.
[20]Hoffman AS. Conventional and environmental-ly sensitive hydrogels for medical and industrial uses. In: DeRossi D, Kajiwara K, Osada Y,Yamuchi A, (editors). Polymer gels. New York:Plenum Press, 1991; pp. 289-97.
[21]Daniluc L, DeKesel CD, David C. Intermolecular interactions in blends of poly(vinyl alcohol) with poly(acrylic acid) 1. FTIR and DSC studies. Eur Polym J1992; 28: 1365-71.
[22]Vazquez-Torres H, Cauich-Rodriguez JV, Cruz Ramos CA. Poly(vinyl alcohol)/poly(acrylic acid)blends: Miscibility studies by DSC and character-ization of their thermally induced hydrogels. JAppl Polym Sci 1993; 50: 777-92.
[23]Katz MG, Wydeven T. Selective permeability of PVAmembranes. I. Radiation-crosslinked membranes. J Appl Polym Sci 1981; 26: 2935-46.
[24]Brunelli D, Atravrs TZ. Study of miscibility of poly(vinyl acetate) and poly(vinyl alcohol) blends by fluorescence spectroscopy.J Appl Polym Sci1995; 55: 889-902.
[25]Lehoussel J, Watteis D, Marechal E. Preparation de membranes echangeuses de cations par photogreffage d'ethers allyliques du poly (alcool vinylique). Etude de certaines de leurs proprietes-II: Photogreffage des poly (alcools vinyliques)allyles.Eur Polym J1979; 15: 915-8.
[26]Shin HS, Kim SY, Lee YM, Lee KH, Kim SJ,Rogers C. Permeation of solutes through interpen-etrating polymer network hydrogels composed of poly(vinyl alcohol) and poly(acrylic acid). J Appl Polym Sci1998; 69: 479-86.
[27]Byun J, Lee YM, Cho C. Swelling of thermosen-sitive interpenetrating polymer networks composed of poly(viny1 alcohol) and poly(acry1icacid). J Appl Polym Sci1996; 61:697-702.
[28]Shin HS, Kim SY, LeeYM. Indomethacin releasebehaviors from pH and thermoresponsive poly(vinyl alcohol) and poly(acrylic acid) IPN hydrogels for site-specific drug delivery. J Appl Polym Sci1997; 65: 685-93.[29]Metayer M, Chamekh OM. Semi-interpenetrating networks (sIPN). Preparation of ion-exchange membranes, using a gaseous crosslinking reagent.React Funct Polymorph1996; 33: 311.
[30]Marra SP, Ramesh KT, Douglas AS. Mechanical characterization of active poly(vinyl alcohol)-poly(acrylic acid) gel.Mater Sci Eng2001; 14:25-34.
[31]Fei J, Zhang Z, Zhong L, Gu L. PVA/PAA thermo-induced hydrogel fiber: Preparation and pH-sensitive behavior in electrolyte solution.J Appl Polym Sci2002; 85: 2423-30.
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