Preparation and Evaluation of Blood Compatibility of NovelEpoxy-Modified Polyurethanes Blood compatible polyurethanes
Iranian Journal of Pharmaceutical Sciences,
Vol. 4 No. 4 (2008),
1 October 2008
,
Page 281-288
https://doi.org/10.22037/ijps.v4.41059
Abstract
In order to prepare polyurethane elastomers with acceptable physical properties and good biocompatibility, novel polyurethane networks were synthesized via curing reaction of epoxy-terminated polyurethane prepolymers (EUPs) with hexamethylene diamine. EUPs were prepared from reaction of glycidol with NCO-terminated polyurethanes (ITPs). ITPs were also synthesized from reaction of one equivalent of either poly(tetramethylene ether)glycol or poly(ethylene glycol) with hexamethylene diisocyanate. Cytotoxcicity and blood compatibility were evaluated.All of the prepared polymers via this novel and simple method showed nontoxic behavior and acceptable blood compatibility.
- Biocompatibility
- Biomaterials
- Blood compatibility
- Polyurethanes
How to Cite
References
[2]Williams DF. Definitions in biomaterials.Amsterdam: Elsevier Science Ltd, 1987.
[3]Ratner BD. The blood compatibility catastrophe.J Biomed Mater Res1993; 27: 283-7.
[4]Wilkes GL. Polymeric science and technology.Morristown: Plenum Press, 1974; p. 45.
[5]Lelah MD, Cooper SL. Polyurethane in medicine.Boca Raton: CRC Press, 1986.
[6]Lamba NMK, Woodhouse KA, Cooper SL.Polyurethanes in biomedical applications Boca Raton: CRC Press, 1998.
[7]Reed AM, Potter J, Szycher M. Asolution grade biostable polyurethane elastomer: Chrono FlexR AR.J BiomaterAppl 1994; 8: 210-36.
[8]Szycher M, Siciliano AA. An assessment of 2,4-TDAformation from surgitek polyurethane foam under simulated physiological conditions. J Biomater Appl1991; 5: 323-36.
[9]Lee H, Neville K. Handbook of epoxy resins.New York: Mc Graw-Hill, 1967.
[10]Chen JH, Wei J, Chang CY, Laiw RF, Lee YD.Studies on segmented polyetherurethane forbiomedical application: Effects of composition and hard-segment content on biocompatibility. J Biomed Mater Res1998; 41: 633-48.
[11]Park JH, Bae YH. Physicochemical properties and in vitrobiocompatibility of PEO/PTMO multiblockco polymer/segmented. Polyurethane blends. J Biomater Sci Polym Ed2002; 13: 527-42.
[12]Grasel TG, Cooper SL. Surface properties and blood compatibility of polyurethaneureas.Biomaterials1986; 7: 315-28.
[13]Cho EH, Yang YI, Mun CW, Kim JK. Tissue-engineered semi-microporous segmented polyetherurethane vascular prostheses. J Biomater Sci Polym Ed2005; 16: 775-90.
[14] Simonovsky FI, Wu Y, Golledge SL, Ratner BD ,J Biomater Sci Polym Ed2005; 16:1463-83.
- Abstract Viewed: 268 times
- IJPS_Volume 4_Issue 4_Pages 281-288 Downloaded: 205 times